Temporal analysis of mRNA expression profiles in Orientia infected C3HeB/FeJ mouse.

ABSTRACT:

Background

Scrub typhus causes up to 35% mortality if left untreated. One billion people living in the endemic regions are at risk. In spite of its heavy disease burden in some of the most populated areas in the world, there is no vaccine available. Although the disease can be effectively treated by proper antibiotics, timely and accurate diagnosis remains a challenge. Orientia tsutsugamushi infects a variety of mammalian cells in vitro and replicates in the cytoplasm of the infected cells. Microarray analysis has been used extensively to study host-pathogen interactions in in vitro models to understand pathogenesis. However there is a lack of in vivo studies.

Results

In this study, C3HeB/FeJ (C3H) mice were infected by O. tsutsugamushi via the intraperitoneal route and moni

SUBMITTER: Chao CC 

PROVIDER: S-EPMC6945539 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature