Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults.

ABSTRACT:

Background

Mounting evidence links poor sleep quality with a higher risk of late-life dementia. However, the structural and cognitive correlates of insomnia are still not well understood. The study aims were to characterize the cognitive performance and brain structural pattern of cognitively unimpaired adults at increased risk for Alzheimer's disease (AD) with insomnia.

Methods

This cross-sectional study included 1683 cognitively unimpaired middle/late-middle-aged adults from the ALFA (ALzheimer and FAmilies) study who underwent neuropsychological assessment, T1-weighted structural imaging (n = 366), and diffusion-weighted imaging (n = 334). The World Health Organization's World Mental Health Survey Initiative version of the Composite International Diagnostic Interview was

SUBMITTER: Grau-Rivera O 

PROVIDER: S-EPMC6945611 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature