Expression of the NEK family in normal and cancer tissue: an immunohistochemical study.

ABSTRACT:

Background

The NEK serine/threonine protein kinases are involved in cell cycle checkpoints, DNA damage repair, and apoptosis. Alterations in these pathways are frequently associated with cell malignant cellular transformations. Thyroid cancer is the most common malignant tumour in the endocrine system. Despite good treatment methods, the number of cases has increased significantly in recent years. Here, we studied the expression of NEK1, NEK2, NEK3, and NEK5 in different types of normal and malignant tissues, using tissue microarray analysis, and identified NEKs as potential markers in thyroid malignancy.

Methods

The studied cases comprised multiple cancer tissue microarrays, including breast, colon, esophagus, kidney, lung, pancreas, prostate, stomach, thyroid and uterine c

SUBMITTER: Melo-Hanchuk TD 

PROVIDER: S-EPMC6945616 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature