Tubular Acidification Defect in Adults with Sickle Cell Disease.

ABSTRACT:

Background and objectives

Metabolic acidosis is a frequent manifestation of sickle cell disease but the mechanisms and determinants of this disorder are unknown. Our aim was to characterize urinary acidification capacity in adults with sickle cell disease and to identify potential factors associated with decreased capacity to acidify urine.

Design, setting, participants, & measurements

Among 25 adults with sickle cell disease and an eGFR of ≥60 ml/min per 1.73 m² from a single center in France, we performed an acute acidification test after simultaneous administration of furosemide and fludrocortisone. A normal response was defined as a decrease in urinary pH <5.3 and an increase in urinary ammonium excretion ≥33 µEq/min at one or more of the six time point

SUBMITTER: Cazenave M 

PROVIDER: S-EPMC6946065 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature