Innate and adaptive immunity associated with resolution of acute woodchuck hepatitis virus infection in adult woodchucks.

ABSTRACT: Viral and/or host factors that are directly responsible for the acute versus chronic outcome of hepatitis B virus (HBV) infection have not been identified yet. Information on immune response during the early stages of HBV infection in humans is mainly derived from blood samples of patients with acute hepatitis B (AHB), which are usually obtained after the onset of clinical symptoms. Features of intrahepatic immune response in these patients are less studied due to the difficulty of obtaining multiple liver biopsies. Woodchuck hepatitis virus (WHV) infection in woodchucks is a model for HBV infection in humans. In the present study, five adult woodchucks were experimentally infected with WHV and then followed for 18 weeks. Blood and liver tissues were frequently collected for assaying marke

SUBMITTER: Suresh M 

PROVIDER: S-EPMC6946171 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature