Association between polymorphisms in microRNAs and susceptibility to diabetes mellitus: A meta-analysis.

ABSTRACT:

Background

Accumulated evidence has indicated the associations between single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) and the susceptibility to diabetes mellitus (DM), but the conclusions remain controversial. This study was to investigate the true contribution of miRNA SNPs to the risk of DM by using a meta-analysis of all the published studies.

Methods

Relevant studies were identified in the databases of PubMed and the Cochrane Library databases. The strength of associations between miRNA polymorphisms and DM risk was assessed by odds ratios (ORs) and 95% confidence intervals (95% CIs) under five genetic models using the STATA software.

Results

Six studies, containing 2773 cases and 2632 controls, were enrolled, 5 of which evaluated miR-146a (rs2910164

SUBMITTER: Chen X 

PROVIDER: S-EPMC6946283 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature