Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at <i>ID2</i>.

ABSTRACT:

Objective

PR interval (PR) is a heritable electrocardiographic measure of atrial and atrioventricular nodal conduction. Changes in PR duration may be associated with atrial fibrillation, heart failure and all-cause mortality. Hispanic/Latino populations have high burdens of cardiovascular morbidity and mortality, are highly admixed and represent exceptional opportunities for novel locus identification. However, they remain chronically understudied. We present the first genome-wide association study (GWAS) of PR in 14 756 participants of Hispanic/Latino ancestry from three studies.

Methods

Study-specific summary results of the association between 1000 Genomes Phase 1 imputed single-nucleotide polymorphisms (SNPs) and PR assumed an additive genetic model and were adjusted for

SUBMITTER: Seyerle AA 

PROVIDER: S-EPMC6946379 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature