Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease.

ABSTRACT:

Background

DNA methylation studies in Parkinson's disease (PD) thus far have focused on disease susceptibility but not progression.

Objective

In this epigenome-wide association study (EWAS), we aim to identify methylation markers associated with faster cognitive decline or motor progression in PD.

Methods

We included 232 PD patients from the Parkinson's Environment and Gene follow-up study who provided blood samples at enrolment. Information on cognitive and motor function was collected using the Mini-Mental State Examination (MMSE) and Unified Parkinson's Disease Rating Scale (UPDRS). For EWAS analyses, we used a robust measure of correlation: biweight midcorrelations, t-tests, and Cox proportional hazard models. We also conducted weighted correlation network analysi

SUBMITTER: Chuang YH 

PROVIDER: S-EPMC6946688 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature