Autoimmunity plays a role in the onset of diabetes after 40 years of age.

ABSTRACT:

Aims/hypothesis

Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of diabetes. However, there are relatively few prospective studies that have characterised the relationship between autoimmunity and incident diabetes. We investigated associations of antibodies against the 65 kDa isoform of GAD (GAD65) with type 1 diabetes and type 2 diabetes genetic risk scores and incident diabetes in adults in European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a case-cohort study nested in the EPIC cohort.

Methods

GAD65 antibodies were analysed in EPIC participants (over 40 years of age and free of known diabetes at b

SUBMITTER: Rolandsson O 

PROVIDER: S-EPMC6946728 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature