Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study.

ABSTRACT:

Aims/hypothesis

We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes.

Methods

We used a risk set sampled nested case-control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched fo

SUBMITTER: Mattila M 

PROVIDER: S-EPMC6946743 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature