Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.

ABSTRACT:

Aims/hypothesis

Insulin resistance in skeletal muscle and liver plays a major role in the pathophysiology of type 2 diabetes. The hyperinsulinaemic-euglycaemic clamp is considered the gold standard for assessing peripheral and hepatic insulin sensitivity, yet it is a costly and labour-intensive procedure. Therefore, easy-to-measure, cost-effective approaches to determine insulin sensitivity are needed to enable organ-specific interventions. Recently, evidence emerged that plasma cathepsin D (CTSD) is associated with insulin sensitivity and hepatic inflammation. Here, we aimed to investigate whether plasma CTSD is associated with hepatic and/or peripheral insulin sensitivity in humans.

Methods

As part of two large clinical trials (one designed to investigate the effects of an

SUBMITTER: Ding L 

PROVIDER: S-EPMC6946744 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature