Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice.

ABSTRACT:

Aims/hypothesis

Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity on offspring islet architecture and/or function, it has not previously been delineated whether these changes are independent of other confounding risk factors such as obesity, postnatal high-fat-feeding and ageing. Thus, we aimed to study the impact of exposure to maternal obesity on offspring islets in young, glucose-tolerant male and female offspring.

Methods

Female C57BL/6J mice w

SUBMITTER: Nicholas LM 

PROVIDER: S-EPMC6946752 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature