Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension.

ABSTRACT:

Purpose

Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment of patients with resistant hypertension, a recent phase III study did not confirm its efficacy. In this study, we developed a novel laparoscopic renal denervation system and evaluated its safety and initial feasibility using an animal model.

Materials and methods

A novel surgical instrument that uses a smart algorithm with temperature-monitoring feedback was developed. We used 4 male pigs (6 weeks old, weighing approximately 45 kg each) to evaluate the safety and efficacy of the laparoscopic renal denervation system. We performed immunohistochemical staining analysis after renal denervation using various tip temperatures and over various durations through an

SUBMITTER: Song WH 

PROVIDER: S-EPMC6946818 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature