Mutations analysis of BRCA1 gene in patients with breast cancer in South Khorasan province, East Iran.

ABSTRACT: Background: Breast cancer (BC) is well-known as the most common malignancy and the first leading cause of cancer-related death among women worldwide. Evidence suggests that familial history and age are important risk factors for the development of this disease in Iran. Mutations in BRCA1 and BRCA2 genes are the cause of 5 to 10% of hereditary BC. Recent studies demonstrated that mutations in BRCA1 were observed in high-risk women with family histories of BC. However, to date, the mutations have not been elucidated in BC patients from east of Iran. The purpose of this study was to analyze BRCA1 mutations in BC patient from South Khorasan Province. Methods: In the present study, 88 BC patients (11 positive family history) were screened for mutations in BRCA1. The analysis of BRCA1 was carrie

SUBMITTER: Khalili-Tanha G 

PROVIDER: S-EPMC6946920 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature