Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers.

ABSTRACT: Greater kyphosis angles lead to increased loading on vertebral bodies in computational models. However, results about the relationship between severity of kyphosis and incident vertebral fracture (VF) risk have been conflicting. Therefore, the aim of this study was to evaluate associations between 1) prevalent VFs and severity of kyphosis, and 2) severity of kyphosis and incident VF risk in smokers with or without chronic obstructive pulmonary disease (COPD). Former and current smokers with or without COPD were included. CT scans were made at baseline, 1-year, and 3-year follow-up. VFs were evaluated on superposed sagittal CT reconstructions. Kyphosis was measured as the angle between the lines above T₄ and below T₉ or T₁₂ . We included 1239 subjects (mean

SUBMITTER: van Dort MJ 

PROVIDER: S-EPMC6946934 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature