A functional polymorphism in the promoter of αA-crystallin increases the risk of nAMD.

ABSTRACT: OBJECTIVE:To analyze the association between the promoter of αA-crystallin (CRYAA) variants with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a northern Chinese population. METHODS:We performed a case-control study in a group of Chinese patients with nAMD (n = 345) or PCV (n = 371) and contrasted the results against an independent control group comprising 514 mild cataract patients without any evidence of age-related maculopathy. An association analysis of allele frequencies was performed for 6 single-nucleotide polymorphisms (SNPs) at the CRYAA locus (rs3761381, rs3761382, rs79545821, rs13053109, rs7278468, and rs117396767). Differences in the observed genotypic distributions between the cases and controls were tested using chi-square

SUBMITTER: Xu H 

PROVIDER: S-EPMC6947115 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature