Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.

ABSTRACT: Computerized device use (CDU) is societally ubiquitous but its effects on mental health are unknown. We performed genetic correlation, Mendelian randomization, and latent causal variable analyses to identify shared genetic mechanisms between psychiatric disorders (Psychiatric Genomics Consortium; 14,477 < N < 150,064) and CDU (UK Biobank; N = 361,194 individuals). Using linkage disequilibrium score regression, we detected strong genetic correlations between "weekly usage of mobile phone in last 3 months" (PhoneUse) vs. attention deficit hyperactivity disorder (ADHD; r_g = 0.425, p = 4.59 × 10^-29) and "plays computer games" (CompGaming) vs. schizophrenia (SCZ; r_g = -0.271, p = 7.16 × 10^-26). F

SUBMITTER: Wendt FR 

PROVIDER: S-EPMC6947231 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature