Sp1 Mediates the Constitutive Expression and Repression of the PDSS2 Gene in Lung Cancer Cells.

ABSTRACT: Prenyl diphosphate synthase subunit 2 (PDSS2) is the first key enzyme in the CoQ₁₀ biosynthesis pathway, and contributes to various metabolic and nephritic diseases. It has been reported that PDSS2 is downregulated in several types of tumors and acts as a potential tumor suppressor gene to inhibit the proliferation and migration of cancer cells. However, the regulatory mechanism of PDSS2 expression remains elusive. In the present study, we first identified and characterized the PDSS2 promoter region. We established four different luciferase reporter constructs which mainly cover the 2 kb region upstream of the PDSS2 gene transcription initiation site. Series luciferase reporter assay demonstrated that all four constructs have prominent promoter activi

SUBMITTER: Hu L 

PROVIDER: S-EPMC6947312 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature