Clinical Inference of Serum and Bone Sclerostin Levels in Patients with End-Stage Kidney Disease.

ABSTRACT: Mounting evidence indicates that sclerostin, a well-known inhibitor of bone formation, may qualify as a clinically relevant biomarker of chronic kidney disease-related mineral and bone disorder (CKD-MBD), including abnormal mineral and bone metabolism and extraskeletal calcification. For this purpose, in this study we investigate the extent to which circulating sclerostin, skeletal sclerostin expression, bone histomorphometric parameters, and serum markers of bone metabolism associate with each other. Bone biopsies and serum samples were collected in a cohort of 68 end-stage kidney disease (ESKD) patients. Serum sclerostin levels were measured using 4 different commercially available assays. Skeletal sclerostin expression was evaluated on immunohistochemically stained bone sections. Quanti

SUBMITTER: Mare A 

PROVIDER: S-EPMC6947521 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature