Prevalence, Risk Factors and Course of Osteoporosis in Patients with Crohn's Disease at a Tertiary Referral Center.

ABSTRACT: Patients with Crohn's disease are at increased risk for fractures due to low bone mineral density (BMD). Real-world data are necessary to optimize surveillance and treatment strategies. Patients with Crohn's disease who underwent at least one dual-energy X-ray absorptiometry (DXA) scans were recruited. The primary study endpoints were (1) prevalence of osteoporosis, and (2) factors influencing changes of BMD. To identify potential risk factors for reduced BMD, Mann-Whitney U-test was used for ordinal and continuous variables and x²-tests for categorical variables. Results with p < 0.05 were included in a multivariable analysis. To identify potential factors influencing changes in BMD, a generalized linear mixed model was applied. 39.9% of the patients were diagnosed with normal BMD, 40.2%

SUBMITTER: Hoffmann P 

PROVIDER: S-EPMC6947604 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature