Dose distribution and up-titration patterns of metformin monotherapy in patients with type 2 diabetes.

ABSTRACT:

Aims

To assess the dose distribution among users of metformin monotherapy as well as the patterns of up-titration following initiation of therapy in people with type 2 diabetes mellitus (T2DM).

Materials and methods

This was a retrospective cohort study of adults with T2DM in the United Kingdom (UK). Metformin dose distribution was assessed at 0, 6 and 12 months in people initiating metformin monotherapy (new users) and cross-sectionally in people with ongoing metformin monotherapy (prevalent users). Patterns and predictors of up-titration were also analysed in new users. Dose distributions and treatment patterns were assessed descriptively; predictors of up-titration were determined using multivariable logistic regressions.

Results

Totals of 6174 new users and 8733 p

SUBMITTER: Iglay K 

PROVIDER: S-EPMC6947691 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature