Effects of long-term antipsychotics treatment on body weight: A population-based cohort study.

ABSTRACT:

Background

Antipsychotics are often prescribed for long-term periods, however, most evidence of their impact on body weight comes from short-term clinical trials. Particularly, impact associated with dosage has been barely studied.

Aims

The aim of this study was to describe the short- and long-term change in body weight of people initiated on high or low doses of the three most commonly prescribed second-generation antipsychotics.

Methods

Retrospective cohorts of individuals with a diagnosed psychotic disorder observed from 2005 to 2015 in the UK primary care. The exposure was the first prescription of olanzapine, quetiapine or risperidone. The main outcome was change in body weight four years before and four years after initiation of antipsychotic treatment, stratifi

SUBMITTER: Bazo-Alvarez JC 

PROVIDER: S-EPMC6947810 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature