Mobile resistome of human gut and pathogen drives anthropogenic bloom of antibiotic resistance.

ABSTRACT:

Background

The impact of human activities on the environmental resistome has been documented in many studies, but there remains the controversial question of whether the increased antibiotic resistance observed in anthropogenically impacted environments is just a result of contamination by resistant fecal microbes or is mediated by indigenous environmental organisms. Here, to determine exactly how anthropogenic influences shape the environmental resistome, we resolved the microbiome, resistome, and mobilome of the planktonic microbial communities along a single river, the Han, which spans a gradient of human activities.

Results

The bloom of antibiotic resistance genes (ARGs) was evident in the downstream regions and distinct successional dynamics of the river resistome occur

SUBMITTER: Lee K 

PROVIDER: S-EPMC6947943 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature