Nucleotide polymorphism assay for the identification of west African group Bacillus anthracis: a lineage lacking anthrose.

ABSTRACT:

Background

The exosporium of the anthrax-causing Bacillus anthracis endospores display a tetrasaccharide composed of three rhamnose residues and an unusual sugar termed anthrose. Anthrose is a proposed potential target for immunotherapy and for specific detection of B. anthracis. Although originally thought to be ubiquitous in B. anthracis, previous work identified an anthrose negative strain from a West African lineage isolated from cattle that could represent a vaccine escape mutant. These strains carry genes required for expression of the anthrose operon but premature stop codons resulting from an 8-bp insertion in BAS3320 (an amino-transferase) and a C/T substitution at position 892 of the BAS3321 (a glycosyltransferase) gene prevent anthrose expression. Various other single nu

SUBMITTER: Zincke D 

PROVIDER: S-EPMC6947953 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature