Non-coding RNAs underlie genetic predisposition to breast cancer.

ABSTRACT:

Background

Genetic variants identified through genome-wide association studies (GWAS) are predominantly non-coding and typically attributed to altered regulatory elements such as enhancers and promoters. However, the contribution of non-coding RNAs to complex traits is not clear.

Results

Using targeted RNA sequencing, we systematically annotated multi-exonic non-coding RNA (mencRNA) genes transcribed from 1.5-Mb intervals surrounding 139 breast cancer GWAS signals and assessed their contribution to breast cancer risk. We identify more than 4000 mencRNA genes and show their expression distinguishes normal breast tissue from tumors and different breast cancer subtypes. Importantly, breast cancer risk variants, identified through genetic fine-mapping, are significantly enriched

SUBMITTER: Moradi Marjaneh M 

PROVIDER: S-EPMC6947989 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature