Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model.

ABSTRACT:

Background

The prevalence of human infections with the zoonotic pathogen Campylobacter jejuni is rising worldwide. Therefore, the identification of compounds with potent anti-pathogenic and anti-inflammatory properties for future therapeutic and/or preventive application to combat campylobacteriosis is of importance for global health. Results of recent studies suggested carvacrol (4-isopropyl-2-methylphenol) as potential candidate molecule for the treatment of campylobacteriosis in humans and for the prevention of Campylobacter colonization in farm animals.

Results

To address this in a clinical murine infection model of acute campylobacteriosis, secondary abiotic IL-10^-/- mice were subjected to synthetic carvacrol via the drinking water starting 4 da

SUBMITTER: Mousavi S 

PROVIDER: S-EPMC6947993 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature