Replication and expansion of epigenome-wide association literature in a black South African population.

ABSTRACT:

Background

DNA methylation is associated with non-communicable diseases (NCDs) and related traits. Methylation data on continental African ancestries are currently scarce, even though there are known genetic and epigenetic differences between ancestral groups and a high burden of NCDs in Africans. Furthermore, the degree to which current literature can be extrapolated to the understudied African populations, who have limited resources to conduct independent large-scale analysis, is not yet known. To this end, this study examines the reproducibility of previously published epigenome-wide association studies of DNA methylation conducted in different ethinicities, on factors related to NCDs, by replicating findings in 120 South African Batswana men aged 45 to 88 years. In addition, no

SUBMITTER: Cronje HT 

PROVIDER: S-EPMC6948000 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature