Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer.

ABSTRACT:

Background

Stage III or IVA endometrial cancer carries a significant risk of systemic and locoregional recurrence.

Methods

In this randomized phase 3 trial, we tested whether 6 months of platinum-based chemotherapy plus radiation therapy (chemoradiotherapy) is associated with longer relapse-free survival (primary end point) than six cycles of combination chemotherapy alone in patients with stage III or IVA endometrial carcinoma. Secondary end points included overall survival, acute and chronic toxic effects, and quality of life.

Results

Of the 813 patients enrolled, 736 were eligible and were included in the analysis of relapse-free survival; of those patients, 707 received the randomly assigned intervention (346 received chemoradiotherapy and 361 received chemotherap

SUBMITTER: Matei D 

PROVIDER: S-EPMC6948006 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature