Multi-cancer V-ATPase molecular signatures: A distinctive balance of subunit C isoforms in esophageal carcinoma.

ABSTRACT:

Background

V-ATPases are hetero-oligomeric enzymes consisting of 13 subunits and playing key roles in ion homeostasis and signaling. Differential expression of these proton pumps has been implicated in carcinogenesis and metastasis. To elucidate putative molecular signatures underlying these phenomena, we evaluated the expression of V-ATPase genes in esophageal squamous cell carcinoma (ESCC) and extended the analysis to other cancers.

Methods

Expression of all V-ATPase genes were analyzed in ESCC by a microarray data and in different types of tumors available from public databases. Expression of C isoforms was validated by qRT-PCR in paired ESCC samples.

Findings

A differential expression pattern of V-ATPase genes was found in different tumors, with combinations in up

SUBMITTER: Couto-Vieira J 

PROVIDER: S-EPMC6948166 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature