A validated composite model to predict risk of curve progression in adolescent idiopathic scoliosis.

ABSTRACT:

Background

In adolescent idiopathic scoliosis (AIS), the continuous search for effective prognostication of significant curve progression at the initial clinical consultation to inform decision for timely treatment and to avoid unnecessary overtreatment remains a big challenge as evidence of the multifactorial etiopathogenic nature is increasingly reported. This study aimed to formulate a composite model composed of clinical parameters and circulating markers in the prediction of curve progression.

Method

This is a two-phase study consisting of an exploration cohort (120 AIS, mean Cobb angle of 25°± 8.5 at their first clinical visit) and a validation cohort (51 AIS, mean Cobb angle of 23° ± 5.0° at the first visit). Patients with AIS were followed-up for a minimum of six yea

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6948250 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature