Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts.

ABSTRACT: The prodrug potential of Mahonia aquifolium, a plant used for centuries in traditional medicine, recently gained visibility in the literature, and the activity of several active compounds isolated from its extracts was studied on biologic systems in vitro and in vivo. Whereas the antioxidative and antitumor activities of M. aquifolium-derived compounds were studied at some extent, there are very few data about their outcome on the immune system and tumor cells. To elucidate the M. aquifolium potential immunomodulatory and antiproliferative effects, the bark, leaf, flower, green fruit, and ripe fruit extracts from the plant were tested on peripheral blood mononuclear cells and tumor cells. The extracts exert fine-tuned control on the immune response, by mo

SUBMITTER: Andreicut AD 

PROVIDER: S-EPMC6948282 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature