Autophagy and Age-Related Eye Diseases.

ABSTRACT:

Background

Autophagy is a catabolic process that depends on the lysosome. It is usually used to maintain cellular homeostasis, survival and development by degrading abnormal substances and dysfunctional organelles, especially when the cell is exposed to starvation or other stresses. Increasing studies have reported that autophagy is associated with various eye diseases, of which aging is one of the important factors.

Objective

To summarize the functional and regulatory role of autophagy in ocular diseases with aging, and discuss the possibility of autophagy-targeted therapy in age-related diseases.

Methods

PubMed searches were performed to identify relevant articles published mostly in the last 5 years. The key words were used to retrieve including "autophagy", "aging

SUBMITTER: Yang X 

PROVIDER: S-EPMC6948295 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature