Low CD4 nadir linked to widespread cortical thinning in adults living with HIV.

ABSTRACT:

Background

The history of immune suppression, especially CD4 nadir, has been shown to be a strong predictor of HIV-associated neurocognitive disorders (HAND). However, the potential mechanism of this association is not well understood.

Methods

High resolution structural MRI images and neuropsychological data were obtained from fifty-nine HIV+ adults (mean age, 56.5 ± 5.8) to investigate the correlation between CD4 nadir and cortical thickness.

Results

Low CD4 nadir was associated with widespread cortical thinning, especially in the frontal and temporal regions, and global mean cortical thickness correlated with CD4 nadir. In addition, worse global neurocognitive function was associated with bilateral frontal cortical thinning, and the association largely persisted (es

SUBMITTER: Hassanzadeh-Behbahani S 

PROVIDER: S-EPMC6948363 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature