Dataset Information

Vitamin D-Binding protein Gene Polymorphism Predicts

ABSTRACT: Background: Vitamin D deficiency is related to poor clinical outcomes in patients with chronic hepatitis B virus

SUBMITTER: Thanapirom K

PROVIDER: S-EPMC6948901 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Vitamin D-Binding protein Gene Polymorphism Predicts Pegylated Interferon-Related HBsAg Seroclearance in HBeAg-Negative Thai Chronic Hepatitis B Patients: A Multicentre Study

Thanapirom Kessarin K Suksawatamnuay Sirinporn S Sukeepaisarnjaroen Wattana W Treeprasertsuk Sombat S Tanwandee Tawesak T Charatcharoenwitthaya Phunchai P Thongsawat Satawat S Leerapun Apinya A Piratvisuth Teerha T Boonsirichan Rattana R Bunchorntavakul Chalermrat C Pattanasirigool Chaowalit C Pornthisarn Bubpha B Tuntipanichteerakul Supot S Sripariwuth Ekawee E Jeamsripong Woramon W Sanpajit Theeranan T Poovorawan Yong Y Komolmit Piyawat P

Asian Pacific journal of cancer prevention : APJCP 20190429 4

Background: Vitamin D deficiency is related to poor clinical outcomes in patients with chronic hepatitis B virus (HBV) infection. Methods: We aimed to investigate the association between the genetic variants in the vitamin D metabolic pathway and the response to pegylated interferon (Peg-IFN) therapy in patients with HBeAg-negative chronic HBV infection. One hundred seven patients treated with Peg-IFN for 48 weeks were selected from 13 specialty hospitals. Eight genotypes of vitamin D cascade ge ...[more]

PMID: 31030503

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Project description:Better knowledge about the possible role of genetic factors in modulating the response to multiple sclerosis (MS) treatment, including rehabilitation, known to promote neural plasticity, could improve the standard of care for this disease. Vitamin D receptor (VDR) gene polymorphisms are associated with MS risk, probably because of the role played by vitamin D in regulating inflammatory and reparative processes. The aim of this study was to evaluate the association of the most important functional VDR SNPs (TaqI (T/C), ApaI (A/C), and FokI (C/T)) with functional outcome in MS patients undergoing multidisciplinary inpatient rehabilitation (MDR) treatment, in order to determine whether genetic profiling might be useful to identify subjects with a higher chance of recovery. To this end, 249 MS inpatients with a diagnosis of either progressive (pMS; n = 155) or relapsing remitting (RRMS; n = 94) disease who underwent MDR treatment (average duration = 5.1 weeks) were genotyped for VDR SNPs by real-time allelic discrimination. The rehabilitation outcome was assessed using the modified Barthel Index (mBI), Expanded Disability Status Scale (EDSS), and pain numerical rating scores (NRS) at the beginning and the end of MDR treatment. A positive correlation was observed in RRMS patients between the VDR TaqI major allele (TT) and mBI increase (i.e., better functional recovery), as assessed by the linear and logistic regression analysis adjusted for gender, age, disease duration, time of hospitalization, HLA-DRB1*15.01 positivity, and number of rehabilitative interventions (Beta = 6.35; p = 0.0002). The VDR-1 TaqI, ApaI, FokI: TCC haplotype was also associated with mBI increase in RRMS patients (Beta = 3.24; p = 0.007), whereas the VDR-2: CAC haplotype was correlated with a lower mBI increase (Beta = -2.18 p = 0.04) compared with the other haplotypes. VDR TaqI major allele (TT), as well as the VDR-1 TaqI, ApaI, FokI: TCC haplotype could be associated with a better rehabilitation outcome in RRMS patients.

Dataset Information

Vitamin D-Binding protein Gene Polymorphism Predicts

Publications

Vitamin D-Binding protein Gene Polymorphism Predicts Pegylated Interferon-Related HBsAg Seroclearance in HBeAg-Negative Thai Chronic Hepatitis B Patients: A Multicentre Study

Similar Datasets

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