Bile acid metabolites control T_H17 and T_reg cell differentiation.

ABSTRACT: Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is unknown whether they affect adaptive immune cells such as T helper cells that express IL-17a (T_H17 cells) or regulatory T cells (T_reg cells). Here we screen a library of bile acid metabolites and identify two distinct derivatives of lithocholic acid (LCA), 3-oxoLCA and isoalloLCA, as T cell regulators in mice. 3-OxoLCA inhibited the differentiation of T_H17 cells by directly binding to the key transcription factor retinoid-related orphan receptor-γt (RORγt) and isoalloLCA increased the differentiation of T_re

SUBMITTER: Hang S 

PROVIDER: S-EPMC6949019 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature