High frequency of shared clonotypes in human B cell receptor repertoires.

ABSTRACT: The human genome contains approximately 20 thousand protein-coding genes¹, but the size of the collection of antigen receptors of the adaptive immune system that is generated by the recombination of gene segments with non-templated junctional additions (on B cells) is unknown-although it is certainly orders of magnitude larger. It has not been established whether individuals possess unique (or private) repertoires or substantial components of shared (or public) repertoires. Here we sequence recombined and expressed B cell receptor genes in several individuals to determine the size of their B cell receptor repertoires, and the extent to which these are shared between individuals. Our experiments revealed that the circulating repertoire of each individual contained between 9 and 1

SUBMITTER: Soto C 

PROVIDER: S-EPMC6949180 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature