Genetic association in female stress urinary incontinence based on proteomic findings: a case-control study.

ABSTRACT:

Introduction and hypothesis

Previous studies have indicated a hereditary component of stress urinary incontinence; however, evidence on candidate genes or single-nucleotide polymorphisms (SNPs) is scarce. We hypothesize a genetic association of female stress urinary incontinence based on significant differences of the urinary and serum proteomic pattern in the identical study population.

Methods

Case-control study of 19 patients and 19 controls. We searched for known SNPs of SUI candidate genes (COL1A1, MMP1, SERPINA5, UMOD) in the database of short genetic variations and PubMed. Genomic DNA was isolated using QIAamp DNA Blood Midi Kit (Qiagen). We performed Sanger sequencing of selected exons and introns.

Results

The rs885786 SNP of the SERPINA5 gene was identified i

SUBMITTER: Reischer T 

PROVIDER: S-EPMC6949200 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature