Improved volumetric myelin imaging in human brain using 3D dual echo inversion recovery-prepared UTE with complex echo subtraction.

ABSTRACT:

Purpose

Inversion recovery-based UTE (IR-UTE) sequences have been proposed to directly image myelin with extremely short T2∗ (~0.3 ms). In this study, we demonstrate the feasibility of complex echo subtraction to improve 3D IR-UTE imaging of myelin in white matter of the brain in vivo.

Methods

In IR-UTE imaging, long T₂ components in white matter (i.e., water) are suppressed using an adiabatic inversion recovery preparation pulse. Dual echo UTE data acquisition and magnitude echo subtraction are used to suppress the residual white matter and gray matter signals, providing high myelin contrast. Complex echo subtraction may further improve the myelin contrast by reducing the residual long T₂ water signal contamination caused by regional T₁ vari

SUBMITTER: Jang H 

PROVIDER: S-EPMC6949380 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature