Development of intravoxel inhomogeneity correction for chemical exchange saturation transfer spectral imaging: a high-resolution field map-based deconvolution algorithm for magnetic field inhomogeneity correction.

ABSTRACT:

Purpose

CEST MRI is sensitive to dilute proteins/peptides and microenvironmental properties yet susceptible to magnetic field inhomogeneity. We aimed to develop a high-resolution field map-based CEST intravoxel inhomogeneity correction (CIVIC) algorithm for CEST Z-spectral imaging.

Methods

The proposed CIVIC approach treats the intravoxel inhomogeneity as a point spread function and applies the deconvolution algorithm to reconstruct the original Z-spectrum. We simulated the effect of B₀ field inhomogeneity on CEST measurement and tested the efficacy of the proposed CIVIC algorithm. We also performed CEST MRI on a dual-pH Creatine-gel phantom under varied field homogeneity conditions and compared the CEST MRI contrast-to-noise ratio from the raw Z-spectrum, water s

SUBMITTER: Sun PZ 

PROVIDER: S-EPMC6949390 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature