Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment.

ABSTRACT:

Background

Ozone (O₃) inhalation elicits airway inflammation and impairs treatment responsiveness in asthmatic patients. The underlying immune mechanisms have been difficult to study because of the lack of relevant experimental models. Rhesus macaques spontaneously have asthma and have a similar immune system to human subjects.

Objectives

We sought to investigate mucosal immune changes after O₃ inhalation in a clinically relevant nonhuman primate asthma model and to study the effects of an antioxidant synthetic lignan (synthetic secoisolariciresinol diglucoside [LGM2605]).

Methods

A cohort of macaques (n = 17) previously characterized with airway hyperreactivity (AHR) to methacholine was assessed (day 1). Macaques were treated (orally) with LGM26

SUBMITTER: Flayer CH 

PROVIDER: S-EPMC6949398 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature