The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology.

ABSTRACT:

Introduction

It is important to establish the natural history of familial frontotemporal lobar degeneration (f-FTLD) and provide clinical and biomarker data for planning these studies, particularly in the asymptomatic phase.

Methods

The Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects protocol was designed to enroll and follow at least 300 subjects for more than at least three annual visits who are members of kindreds with a mutation in one of the three most common f-FTLD genes-microtubule-associated protein tau, progranulin, or chromosome 9 open reading frame 72.

Results

We present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in wh

SUBMITTER: Boeve B 

PROVIDER: S-EPMC6949411 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature