Long-term survival and differentiation of human thymocytes in human thymus-grafted immunodeficient mice.

ABSTRACT: Aim: Thymus transplants have produced encouraging clinical outcomes in achieving thymopoiesis and T-cell development. This study was aimed to investigate whether human thymus contains self-renewing lymphoid progenitors capable of maintaining long-term T-cell development. Materials & methods: Immunodeficient mice were transplanted with human thymic tissue along with autologous GFP-expressing or allogeneic CD34⁺ cells and followed for human thymopoiesis and T-cell development from the thymic progenitors versus CD34⁺ cells, which can be distinguished by GFP or HLA expression. Results: In both models, long-term thymopoiesis and T-cell development from the thymic grafts were detected. In these mice, human thymic progenitor-derived T cells including CD4

SUBMITTER: Tang Y 

PROVIDER: S-EPMC6949514 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature