Ontology highlight
ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC6949560 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ma Jian J Yin Bin B Shi Jia-Yu JY Lin Yan-Song YS Duan Shi-Jun SJ Shi Bing B Jia Zhong-Lin ZL
International journal of clinical and experimental pathology 20190701 7
<h4>Objective</h4>Non-syndromic oral cleft (NSOC) is one of the most common multifactorial birth defects. A previous animal study showed <i>PBX1</i> gene knockout mice consequently exhibited complete cleft lip/palate (CL/P). However, little is known about the association between <i>PBX1</i> and NSOC in humans. This study investigated the role of the <i>PBX1</i> gene in NSOC in the Han Chinese population.<h4>Methods</h4>In all, 287 NSOCs were recruited for this study. First, exons in the <i>PBX1< ...[more]