Refinement for single-nanoparticle structure determination from low-quality single-shot coherent diffraction data.

ABSTRACT: With the emergence of X-ray free-electron lasers, it is possible to investigate the structure of nanoscale samples by employing coherent diffractive imaging in the X-ray spectral regime. In this work, we developed a refinement method for structure reconstruction applicable to low-quality coherent diffraction data. The method is based on the gradient search method and considers the missing region of a diffraction pattern and the small number of detected photons. We introduced an initial estimate of the structure in the method to improve the convergence. The present method is applied to an experimental diffraction pattern of an Xe cluster obtained in an X-ray scattering experiment at the SPring-8 Angstrom Compact free-electron LAser (SACLA) facility. It is found that the electron density is

SUBMITTER: Nishiyama T 

PROVIDER: S-EPMC6949595 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature