Osteoprotegerin promotes islet β cell proliferation in intrauterine growth retardation rats through the PI3K/AKT/FoxO1 pathway.

ABSTRACT: Osteoprotegerin (OPG) is a critical factor involved in bone metabolism. The level of OPG is increased in the serum of diabetic patients; however, there is no consensus in prior studies on the role of OPG in regulating the function of islet β cells. A rat model of intrauterine growth retardation (IUGR) was established in the present study to investigate whether OPG could enhance the proliferation of β cells; and an in vitro culture model of rat islet β cell line INS-1 was used, to confirm the effect of OPG supplementation and reveal the possible mechanism. The results showed that endogenous OPG expression was reduced and normal proliferation of β cells was impaired in the IUGR islets. Exogenous supplement of OPG restored β cell proliferation to an extent in the IUGR rats, possibly associate

SUBMITTER: Tang S 

PROVIDER: S-EPMC6949609 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature