A single nucleotide polymorphism CTSB rs12898 is associated with primary hepatic cancer in a Chinese population.

ABSTRACT:

Background & aims

Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, the molecular mechanisms underlying hepatic cancer remain unknown. CTSB is considered a biomarker of cancer as it can facilitate tumor progression. We aimed to investigate the association between genetic polymorphisms of potential regulatory SNPs in the CTSB gene and PHC.

Methods

The relationship between CTSB rs12898 and PHC was analyzed in a case-control study with a Chinese population of 608 PHC patients and 608 healthy individuals using SPSS 21.0.

Results

PHC was significantly associated with alcohol consumption (P < 0.001), history of hepatitis (P < 0.001), and liver cirrhosis (<

SUBMITTER: Cui M 

PROVIDER: S-EPMC6949695 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature