Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model.

ABSTRACT: There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (T_reg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4⁺CD25⁺FoxP3⁺ T_regs from donors improves litter sizes in DEREG mice with depleted T_regs. Our hypothesis is that DEREG mice treated with a single dose of DT will deplete T_regs and subsequently decrease litter sizes and

SUBMITTER: Royster GD 

PROVIDER: S-EPMC6949958 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature