Marine Bacteria from Rocas Atoll as a Rich Source of Pharmacologically Active Compounds.

ABSTRACT: Rocas Atoll is a unique environment in the equatorial Atlantic Ocean, hosting a large number of endemic species, however, studies on the chemical diversity emerging from this biota are rather scarce. Therefore, the present work aims to assess the metabolomic diversity and pharmacological potential of the microbiota from Rocas Atoll. A total of 76 bacteria were isolated and cultured in liquid culture media to obtain crude extracts. About one third (34%) of these extracts were recognized as cytotoxic against human colon adenocarcinoma HCT-116 cell line. 16S rRNA gene sequencing analyses revealed that the bacteria producing cytotoxic extracts were mainly from the Actinobacteria phylum, including Streptomyces, Salinispora, Nocardiopsis, and Brevibacterium genera, an

SUBMITTER: Velasco-Alzate KY 

PROVIDER: S-EPMC6949966 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature