Plasma Phospholipid Fatty Acids, <i>FADS1</i> and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.

ABSTRACT: Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA levels and 15 CVDs. Summary-level data from the CARDIoGRAMplusC4D, MEGASTROKE, and Atrial Fibrillation consortia and UK Biobank were used. Sixteen single-nucleotide polymorphisms (SNPs) associated with ten plasma FAs were used as instrumental variables. SNPs in or close to the FADS1 gene were associated with most FAs. We performed a secondary analysis of the association between a functional variant (rs174547) in FADS1, which encodes ?5-desaturase (a key enzyme in the endogenous FA synthesis), and CVD. Genetic predisposition to higher plasma α-linoleni

SUBMITTER: Yuan S 

PROVIDER: S-EPMC6950527 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature