Diversity and Evolution of Novel Invertebrate DNA Viruses Revealed by Meta-Transcriptomics.

ABSTRACT: DNA viruses comprise a wide array of genome structures and infect diverse host species. To date, most studies of DNA viruses have focused on those with the strongest disease associations. Accordingly, there has been a marked lack of sampling of DNA viruses from invertebrates. Bulk RNA sequencing has resulted in the discovery of a myriad of novel RNA viruses, and herein we used this methodology to identify actively transcribing DNA viruses in meta-transcriptomic libraries of diverse invertebrate species. Our analysis revealed high levels of phylogenetic diversity in DNA viruses, including 13 species from the Parvoviridae, Circoviridae, and Genomoviridae families of single-stranded DNA virus families, and six double-stranded DNA virus species from the Nudiviridae, Pol

SUBMITTER: Porter AF 

PROVIDER: S-EPMC6950620 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature